Speaker(s): 

John Horne, MD, Resident, Geisinger - has nothing to disclose.

Valeria Moseley, MD, Resident, Geisinger - has nothing to disclose.

Moderator(s): 

Zachary Hoffer, MD, Staff Physician, Geisinger - has nothing to disclose. 

Learning Objectives: 

At the conclusion of this session, the participant should be able to: 

• Explain what transfusion associated circulatory overload (TACO) is and why it's a significant and potentially fatal transfusion reaction. 
• Identify risk factors that predispose patients to TACO and incorporate that into their transfusion management. 
• Describe the genetic subtypes of classic Hodgkin lymphoma (cHL) identified through circulating tumor DNA (ctDNA) analysis, and explain how mechanisms of genetic instability—rather than functional DNA alterations—drive these subtypes.
• Discuss the clinical implications of ctDNA-based profiling in cHL, including its role in risk stratification, treatment personalization, and the identification of novel mutational hotspots such as the BCL6 super enhancer.

Disclosure of Relevant Financial Relationships without Commercial Interests:

The Planning Committee consisting of Zachary Hoffer, MD PhD have no identified disclosures. 

CE Committee Member/Content Reviewers have nothing to disclose. 

Any/All relevant financial relationships have been mitigated. 

Content Disclosure:  None.

This presentation/content is HIPAA compliant. 

Commercial Support for this Session:  None.